This was my second set of S22's so I had some experience already on another one of my bikes. I've been happy with them on my R1M after switching from RS10's for better life, and have been waiting to replace the S21's on my GSXR1000. After 3 seasons, the S21's finally died with good even wear across the carcass. I did notice much more wear on the front than I am used to seeing from hard cornering which didn't allow for the usual "replace two rears for every front", but I got great life from the pair and the improvement in handling going to fresh S22's from shagged S21's was worth it.
With the R1M I didn't notice a huge handling difference going from the RS10's to the S22's, but it was really noticeable on the GSXR. It is stable in a straight line but a hell of a lot more willing to fall onto it's side with light bar pressure-I thought I got my tire pressures wrong when I first rode it. I've got a few hundred miles on them now on good twisty roads and have gotten used to it.
Speaking of pressures, I am running these 5psi lower than recommended. I had tire life problems with the RS10's until I started doing this and it changed the handling for the better and helped with tire life because the carcass can deform more which reduces flat spotting from straight like riding. It also allows the tired to get more heat in it which reduces cold tearing because it isn't hot and sticky when you ask it to accelerate hard.
Bridgestone says these tires are slightly better in all of their metrics that they grade their tires on compared to the S21 with the exception of rain performance where it is quite a bit better than the older S21. I can't attest to any of that, but I got great life and performance out of the S21's and expect more of the same... The R1 has almost a season of hard riding on it and the tires haven't flat spotted or shown any noticeable wear even though I'm pretty hard on tires. I'd recommend these to anyone, or the S21's if money is tight but the cost difference is pretty small.